Laboratory of Experimental Nuclear Medicine with a Group of "Isotope"
The laboratory was founded in 1994.
In the laboratory 39 employees, including 2 doctors and 11 candidates of science.
The main activities
In the sphere of science:
Find, design and development of new diagnostic and therapeutic radiopharmaceuticals purpose, methods of synthesis and quality control of radiopharmaceuticals, the study of their pharmacokinetic and dosimetric characteristics, the study diagnostic informative and therapeutic efficacy produced radiopharmaceuticals for in vivo radionuclide diagnosis and therapy.
Find and create new means of radionuclide in vitro diagnostics and other specific test systems for the diagnosis of various diseases and the evaluation of the impact of extreme factors on the body, the development of methods for the preparation and quality control reagents for in vitro diagnostics.
Development of modern instrumental methods of retrospective and prospective individual dosimetry methods based on electron paramagnetic and nuclear magnetic spectroscopy, the use of techniques developed for the study of laws of formation of individual doses for different categories of persons exposed to radiation as a result of radiation accidents and nuclear weapons tests in the detection of This group-based high "health risk."
In the industrial sector:
Issuance of experimental batches of reagents for radionuclide generator for in vivo diagnosis and therapy, as well as sets of reagents for in vitro diagnostics.
Provide clinical departments of the Center radionuclide medical products from the manufacturers to carry out diagnostic procedures and treatment of various diseases.
The main results
Was a very fruitful working to find new radiopharmaceuticals for radionuclide diagnosis and therapy of socially significant diseases, including cancer. Justified and has arranged not only the synthesis of these drugs, but also radiobiological and therapeutic support for new radiopharmaceuticals. Interesting materials complex Radiochemical, pharmacokinetic and dosimetric studies of radiopharmaceuticals based on the native albumin and albumin microspheres nanoalbumina labeled with radionuclides iodine-131, indium-111, technetium-99m, lutetium-177, rhenium-188, palladium-103, depending on the their preparation and physico-chemical characteristics. The technology of production and other original products, in particular 166Ho. For the first time the possibility of obtaining labeled albumin microspheres by activation of stable isotopes in the protein particles by thermal neutrons (152mEu, 177Lu, 186Re, 166Ho).
Show the influence of pre-gamma irradiation of laboratory animals on the pharmacokinetics of labeled albumin microspheres. Original methods of comparative evaluation of internal radiation absorbed doses of organs and tissues of laboratory animals, depending on the type of radionuclide. The results of the research for a number of radiopharmaceuticals prepared laboratory regulations for their synthesis, development, industrial regulations for the practical production, the company standards for quality control of drugs. Preclinical and clinical studies, the permission for the industrial production of 99mTc-albumin microspheres, the drug is registered in the register of medicines, and received permission for its industrial production. The patents of the Russian Federation "A method for producing a radionuclide-labeled microspheres" and "Method of radiofarpreparata for radionuclide therapy."
After the Chernobyl accident have been carried out extensive measurements of individual accumulated doses (over 7,500 cases) in the population of radioactively contaminated territories of Bryansk, Kaluga and Tula regions, as well as the liquidators of the accident. On this basis, the regularities of the formation of doses, depending on the density of radioactive contamination of territories, age, etc. The inhabitants of the Laboratory of Experimental Nuclear Medicine MRRC bank formed tooth enamel samples for subsequent refinement of measurements with the improvement of hardware and software ESR. Set up an information database "Individual accumulated doses of ionizing radiation in patients undergoing uncontrolled radiation exposure identified by EPR spectroscopy on samples of tooth enamel" (certificate of state registration of the database number 2011620641 from 12.09.2011, the).
In the laboratory the continuous development and improvement of EPR spectroscopy for biomedical purposes. Work has begun on the definition of absorbed dose from samples of bone amputated limbs in the case of acute accidental exposure. The method is widely used in basic radiobiology research related to the biological effects of neutrons, the search for new radioprotective agents based on biomediatora - nitric oxide (NO) and its synthesis inhibitors, the study of the rate of calcium in the bones, etc.
The laboratory has taken an active part in four international interslicheniyah determination of absorbed dose by EPR spectroscopy of human tooth enamel. Among the 19 laboratories from different countries the results obtained in the laboratory, were among the best, demonstrating the high accuracy and reliability. Two employees of the laboratory came from the Russian State Standard of the experts of the International Organization for Standardization (ISO) in "Biological Dosimetry." Develops international standards for ESR.
The laboratory regularly participates in the implementation of federal programs.
Laboratory staff were part of the three teams who won competitions for grants of the President of the Russian Federation for State Support of Leading Scientific Schools: NSH-2944.2006.7 "Reconstruction of accumulated doses from external photon radiation and internal exposure from incorporated radionuclides cesium and strontium by EPR spectroscopy and beta spectrometry enamel of human teeth "(2006-2007 gg.), NSH-347.2008.7" retrospective dosimetry in nuclear medicine, nuclear medicine and radiation safety "(2008-2009). NSH-919.2012.7 and" Development of innovative radiopharmaceuticals drugs by using a target carrier and generator radionuclide 99mTc and 188Re for the diagnosis and therapy of tumors of different localization "(2012-2013)..
The laboratory carries out international scientific and business contacts with foreign companies and organizations:
- Radiopharmaceutical company «CIS-Bio International» (Paris, France);
- National Research Center for Environment and Health to them. Helmholtz (Munich, Germany);
- Institute of Radiation Protection and Nuclear Safety (Paris, France);
- University of Hiroshima (Hiroshima, Japan);
- Dartmouth College (Hanover, New Hampshire, USA), etc.
Research and teaching activities
The laboratory operates with 2009 Research and Education Center of Nuclear Medicine and Radiopharmaceuticals.
Laboratory scientists teach in the Department of Biology INPE MEPhI.
List of main publications of the laboratory see here.
Laboratory Head - PhD Skvortsov Valery G.
Tel +7 (484) 399-70-34